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MECHANISM OF ACTION:
Clavulanic Acid protects amoxycillin from degradation by beta-lactamase enzymes. Hence it extends the antibiotic spectrum of amoxycillin to include many bacteria normally resistant to amoxycillin. Amoxycillin exerts its action by inhibiting the bacterial cell wall synthesis.
PHARMACOKINETICS:
After oral administration amoxycillin and clavulanic acid are well absorbed from GIT. Clavulanic acid does not affect the absorpion of amoxycillin. The plasma protein binding of clavulanic acid is approximately 20%. Both drugs diffuse rapidly into most tissues and fluids of body with the exception of brain. The plasma half-life of amoxycillin is 1.3 hours and of clavulanic acid is 1 hour. Approximately 50-70% of amoxycillin and 20-40% of clavulanic acid excreted unchanged in urine during the first 6 hours of oral administration.
Onset of Action: 1-2 hours.
Duration of Action: 8 hours
ADVERSE EFFECTS:
Nausea, vomiting, diarrhea, skin rash, uriticaria, indigestion, abdominal discomfort, flatulence, headache, pseudomembranous colitis, candidiasis
CONTRAINDICATIONS:History of allergy to any Penicillin
SPECIAL PRECAUTIONS:History of allergy to cephalosporins.
PREGNANCY :Safety not established
LACTATION:Use with caution
ELDERLY: May be used with caution
INDICATIONS:
Moximax is indicated for infections due to penicillinase producing strains (where amoxycillin alone is not appropriate). Upper respiratory tract infections- Tonsillitis Otitis media Lower respiratory tract infections. Acute and chronic bronchitis, lobar, and bronchopneumonia.
Genital tract infections - Cystitis, pyelonephritis, urethritis, Skin and soft tissue infections, cellulitis, wound infections, abscess.
DOSAGE AND ADMINISTRATION:
Adults: Pneumonia and serious infections: 500 mg amoxycillin + 125 mg Clavulanic Acid every 8 hours for 7-10 days.
In other infections: 250 mg amoxycillin + 125 mg Clavulanic Acid every 8 hours for 7-10 days.
Children: Upto 40 kg of body weight:
6.7 mg amoxycillin and 1.7 mg clavulanic acid per kg body weight every 8-hour for 7-10 days.
For severe infections: 13.3 mg amoxycillin and 3.3 mg clavulanic acid per kg body weight every 8 hour for 7-10 days.
INSTRUCTIONS:
Capsule is not to be crushed or chewed. It is to be swallowed as whole along with water. |
