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DESCRIPTION:
Ciprolac contains Ciprofloxacin, a broad spectrum fluoroquinolone with activity against Pseudomonas aeruginosa. Fluoroquinolones are efficacious, well tolerated bactericidal drug, with broad spectrum of antimicrobial activity and exhibit excellent bioavailability. Ciprolac TZ has tinidazole, which is a potent amoebicide. The advantage of the combination is its effectiveness against both bacteria and protozoa. Lactobacillus sporogenes in Ciprolac helps in preventing diarrhoea and also maintain normal intestinal Flora which is usually disturbed with the action of antibiotics.
MECHANISM OF ACTION:
Ciprofloxacin acts by inhibiting bacterial DNA gyrase enzyme which is required for DNA replication and thus cause bacteriallysis.
MICROBIOLOGY:
Ciprolac possess excellent activity against members of Enterbacteriaceae family, Pseudomonas aeruginosa, H.influenzae, N. gonorrhoea, N. menin-gitidis and Moraxella catarrhalis. It also exhibit good activity against Staph. aureus and Staph. epidermidis isolates that are methicillin susceptible.
PHARMACOKINETICS:
Rapidly absorbed after oral administration, it is has the best tissue penetration amongst Fluoroquinolones.
Onset of Action: Within 1 hour.
Duration of Action: 8-12 hours
ADVERSE SIDE EFFECTS:
Nausea, vomiting, epigastric distress, headache, restlessness, abdominal pain, diarrhoea, skin rashes, insomnia, confusion, dizziness and arthralgia
CONTRA-INDICATIONS:Hypersensitivity
SPECIAL PRECAUTIONS:Renal dysfunction, epilepsy. Prolonged use, children.
INTERACTIONS: Antacids (aluminium/magnesium hydroxide), iron salts, Zinc salts: Absorption of ciprofloxacin is decreased. Antineoplastic drugs: Decrease serum levels of ciprofloxacin.
Caffeine: Enhanced efficacy of caffeine.
Oral anti-coagulants: Enhanced efficacy of anti coagulants.
Cyclosporine: Nephrotoxicity increased by ciprofloxacin.
NSAIDs: CNS excitation may occur.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
Rifampicin: Decreases serum concentration of ciprofloxacin.
Chloramphenicol: Antagonises effects of ciprofloxacin.
USAGE IN PREGNANCY, LACTATION AND ELDERLY PEOPLE :Use with caution.
INDICATIONS:
Respiratory tract, Urinary tract, E.N.T., skin and soft tissue, GI tract, intra-abdominal, gynaecological. Bone and joint, severe systemic infections Gonorrhoea, Prostatitis, throat infection, enteric fever and eye infection.
USUAL DOSAGE AND ADMINISTRATION:
Adults: The dosage is determined on the basis of severity of infection, type of infecting organism and age, weight and renal function of the patient. the recommended dosage of oral ciprolac is as follows:
Uncomplicated UTI: 250 mg every 12 hours.
Prostatitis and complicated UTI in patients with severe underlying structural abnormalities: 500 mg every 12 hours.
Lower respiratory tract infections: mild 250 mg; moderate to severe 500 mg every 12 hours.
ENT infections: 500 to 750 mg every 12 hours.
Bone and joint infections: 500 to 750 mg every 12 hours.
Children: not recommended. |
